STAT1-S727 - the license to kill
نویسندگان
چکیده
منابع مشابه
A License to Kill
Much of our knowledge of the basal mechanism underly-44 Lincoln's Inn Fields ing programmed cell death derives from the elegant London WC2A 3PX studies of Horvitz and colleagues on developmental cell United Kingdom death in the developmentally deterministic nematode worm Caenorhabditis elegans. During development of Apoptosis is the descriptive name given to the process the hermaphrodite worm, ...
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Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on tyrosine phosphorylation of STATs, but the role of serine STAT1 phosphorylation remains unclear. We previously demonstrated that Mediator kinase inh...
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The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of perforin and granzyme B. Stat1-S727A mice display significantly delayed disease...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2014
ISSN: 2162-402X
DOI: 10.4161/21624011.2014.955441